Hologenomics: Systems-Level Host Biology
نویسندگان
چکیده
منابع مشابه
Host-pathogen systems biology.
Unlike traditional biological research that focuses on a small set of components, systems biology studies the complex interactions between a large number of genes, proteins and other elements of biological networks and systems. Host-pathogen systems biology examines the interactions between the components of two distinct organisms, either a microbial or viral pathogen and its animal host or two...
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Viruses have evolved to manipulate the host cell machinery for virus propagation, in part by interfering with the host cellular signaling network. Molecular studies of individual pathways have uncovered many viral host-protein targets; however, it is difficult to predict how viral perturbations will affect the signaling network as a whole. Systems biology approaches rely on multivariate, contex...
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Pathogens manipulate the cellular mechanisms of host organisms via pathogen-host interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to infections. The crucial role of these interspecies molecular interactions in initiating and sustaining infections necessitates a thorough understanding of the corresponding mechanisms. Unlike the traditional approach of con...
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Pathogen-Host Interactions (PHIs) play a significant role in the mechanisms of infections. Therefore, the investigation of infectionmechanisms through PHIs is a crucial step to develop novel and more effective solutions against drug-resistance and for personalized therapy. To this aim, systems biology approach considers the whole PHI system instead of focusing hosts or pathogens individually. C...
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ژورنال
عنوان ژورنال: mSystems
سال: 2018
ISSN: 2379-5077
DOI: 10.1128/msystems.00164-17